Abnormalities in
redox metabolism and
oxidative stress in
autism spectrum disorder
Literature Review of
Redox Metabolism Abnormalities in
Autism Spectrum disorder
Metabolic pathology of autism in relation to redox metabolism.
Frye RE, James SJ. Biomark Med. 2014; 8(3):321-30.
Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.
Rossignol DA, Frye RE. Front Physiol. 2014; 5:150.
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.
Rossignol DA, Frye RE.
Mol Psychiatry. 2012; 17(4):389-401.
Treatment for redox abnormalities in autism spectrum disorder
Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials.
Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE. C Front Neurosci. 2018; 12:19.
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R.
Neurosci Biobehav Rev. 2015; 55:294-321.
Treatments for biomedical abnormalities associated with autism spectrum disorder.
Frye RE, Rossignol DA. Front Pediatr. 2014; 2:66.
Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes.
Frye RE, Rossignol DA. Clin Med Insights Pediatr. 2016; 10:43-56.
Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status.
Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW, Walters L, James SJ. Autism Res Treat. 2013; 2013:609705.
Redox abnormalities are linked to mitochondrial dysfunction in autism spectrum disorder
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain.
Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE, James SJ. Transl Psychiatry. 2012 Jul 10;2:e134.
Redox metabolism abnormalities in autistic children associated with mitochondrial disease.
Frye RE, Delatorre R, Taylor H, Slattery J, Melnyk S, Chowdhury N, James SJ. Transl Psychiatry. 2013; 3:e273.
Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort.
Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Pavliv O, Melnyk S, James SJ.
PLoS One. 2014; 9(1):e85436.
Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines.
ose S, Frye RE, Slattery J, Wynne R, Tippett M, Melnyk S, James SJ. Transl Psychiatry. 2014; 4:e377.
Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study.
Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE.
FASEB J. 2017; 31(3):904-909.
Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines.
Frye RE, Rose S, Wynne R, Bennuri SC, Blossom S, Gilbert KM, Heilbrun L, Palmer RF. Sci Rep. 2017; 7(1):4478.